An intrastrand d(GpG) platinum crosslink in duplex M13 DNA is refractory to repair by human cell extracts.

We have examined the ability of human cell extracts to repair the most frequent DNA adduct caused by the cancer chemotherapeutic agent cis-diamminedichloroplatinum(II). A circular DNA duplex with an intrastrand d(GpG) crosslink positioned at a specific site was synthesized. Human cell extracts were...

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Bibliografski detalji

Izdano u:	Proc Natl Acad Sci U S A
Glavni autori:	Szymkowski, D E, Yarema, K, Essigmann, J M, Lippard, S J, Wood, R D
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 1992
Teme:	Research Article
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50424/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1438274/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.22.10772
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