An intrastrand d(GpG) platinum crosslink in duplex M13 DNA is refractory to repair by human cell extracts.

We have examined the ability of human cell extracts to repair the most frequent DNA adduct caused by the cancer chemotherapeutic agent cis-diamminedichloroplatinum(II). A circular DNA duplex with an intrastrand d(GpG) crosslink positioned at a specific site was synthesized. Human cell extracts were...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Szymkowski, D E, Yarema, K, Essigmann, J M, Lippard, S J, Wood, R D
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1992
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50424/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1438274/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.22.10772
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