An intrastrand d(GpG) platinum crosslink in duplex M13 DNA is refractory to repair by human cell extracts.

We have examined the ability of human cell extracts to repair the most frequent DNA adduct caused by the cancer chemotherapeutic agent cis-diamminedichloroplatinum(II). A circular DNA duplex with an intrastrand d(GpG) crosslink positioned at a specific site was synthesized. Human cell extracts were...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Szymkowski, D E, Yarema, K, Essigmann, J M, Lippard, S J, Wood, R D
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 1992
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50424/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1438274/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.22.10772
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