An intrastrand d(GpG) platinum crosslink in duplex M13 DNA is refractory to repair by human cell extracts.

We have examined the ability of human cell extracts to repair the most frequent DNA adduct caused by the cancer chemotherapeutic agent cis-diamminedichloroplatinum(II). A circular DNA duplex with an intrastrand d(GpG) crosslink positioned at a specific site was synthesized. Human cell extracts were...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Szymkowski, D E, Yarema, K, Essigmann, J M, Lippard, S J, Wood, R D
Format: Artigo
Sprog:Inglês
Udgivet: 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC50424/
https://ncbi.nlm.nih.gov/pubmed/1438274
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker