Merlin inhibits Wnt/β-catenin signaling by blocking LRP6 phosphorylation

Merlin, encoded by the NF2 gene, is a tumor suppressor that acts by inhibiting mitogenic signaling and is mutated in Neurofibromatosis type II (NF2) disease, although its molecular mechanism is not fully understood. Here, we observed that Merlin inhibited Wnt/β-catenin signaling by blocking phosphor...

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Publicado en:Cell Death Differ
Autores principales: Kim, M, Kim, S, Lee, S-H, Kim, W, Sohn, M-J, Kim, H-S, Kim, J, Jho, E-H
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Original Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041192/
https://ncbi.nlm.nih.gov/pubmed/27285107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.54
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