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Merlin inhibits Wnt/β-catenin signaling by blocking LRP6 phosphorylation
Merlin, encoded by the NF2 gene, is a tumor suppressor that acts by inhibiting mitogenic signaling and is mutated in Neurofibromatosis type II (NF2) disease, although its molecular mechanism is not fully understood. Here, we observed that Merlin inhibited Wnt/β-catenin signaling by blocking phosphor...
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| Publié dans: | Cell Death Differ |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5041192/ https://ncbi.nlm.nih.gov/pubmed/27285107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.54 |
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