Merlin inhibits Wnt/β-catenin signaling by blocking LRP6 phosphorylation

Merlin, encoded by the NF2 gene, is a tumor suppressor that acts by inhibiting mitogenic signaling and is mutated in Neurofibromatosis type II (NF2) disease, although its molecular mechanism is not fully understood. Here, we observed that Merlin inhibited Wnt/β-catenin signaling by blocking phosphor...

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Vydáno v:Cell Death Differ
Hlavní autoři: Kim, M, Kim, S, Lee, S-H, Kim, W, Sohn, M-J, Kim, H-S, Kim, J, Jho, E-H
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041192/
https://ncbi.nlm.nih.gov/pubmed/27285107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.54
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