Merlin inhibits Wnt/β-catenin signaling by blocking LRP6 phosphorylation

Merlin, encoded by the NF2 gene, is a tumor suppressor that acts by inhibiting mitogenic signaling and is mutated in Neurofibromatosis type II (NF2) disease, although its molecular mechanism is not fully understood. Here, we observed that Merlin inhibited Wnt/β-catenin signaling by blocking phosphor...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Differ
Prif Awduron: Kim, M, Kim, S, Lee, S-H, Kim, W, Sohn, M-J, Kim, H-S, Kim, J, Jho, E-H
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Original Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041192/
https://ncbi.nlm.nih.gov/pubmed/27285107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.54
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