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A single molecule assay to probe monovalent and multivalent bonds between hyaluronan and its key leukocyte receptor CD44 under force

Glycosaminoglycans (GAGs), a category of linear, anionic polysaccharides, are ubiquitous in the extracellular space, and important extrinsic regulators of cell function. Despite the recognized significance of mechanical stimuli in cellular communication, however, only few single molecule methods are...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Bano, Fouzia, Banerji, Suneale, Howarth, Mark, Jackson, David G., Richter, Ralf P.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5040960/
https://ncbi.nlm.nih.gov/pubmed/27679982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34176
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