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A single molecule assay to probe monovalent and multivalent bonds between hyaluronan and its key leukocyte receptor CD44 under force

Glycosaminoglycans (GAGs), a category of linear, anionic polysaccharides, are ubiquitous in the extracellular space, and important extrinsic regulators of cell function. Despite the recognized significance of mechanical stimuli in cellular communication, however, only few single molecule methods are...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Bano, Fouzia, Banerji, Suneale, Howarth, Mark, Jackson, David G., Richter, Ralf P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5040960/
https://ncbi.nlm.nih.gov/pubmed/27679982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34176
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