Synergistic anti-leukemic interactions between ABT-199 and panobinostat in acute myeloid leukemia ex vivo

Cure rates for acute myeloid leukemia (AML) remain suboptimal; thus new treatment strategies are needed for this deadly disease. Poor clinical outcomes have been associated with overexpression of the anti-apoptotic Bcl-2 family proteins Bcl-2, Bcl-xL, and Mcl-1, which have garnered great interest as...

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Veröffentlicht in:Am J Transl Res
Hauptverfasser: Schwartz, Jonathan, Niu, Xiaojia, Walton, Eric, Hurley, Laura, Lin, Hai, Edwards, Holly, Taub, Jeffrey W, Wang, Zhihong, Ge, Yubin
Format: Artigo
Sprache:Inglês
Veröffentlicht: e-Century Publishing Corporation 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5040686/
https://ncbi.nlm.nih.gov/pubmed/27725868
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