Synergistic anti-leukemic interactions between panobinostat and MK-1775 in acute myeloid leukemia ex vivo

MK-1775 is the first-in-class selective Wee1 inhibitor which has been demonstrated to synergize with CHK1 inhibitors in various malignancies. In this study, we report that the pan-histone deacetylase inhibitor (HDACI) panobinostat synergizes with MK-1775 in acute myeloid leukemia (AML), a malignancy...

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Detalhes bibliográficos
Publicado no:Cancer Biol Ther
Main Authors: Qi, Wenxiu, Zhang, Wenbo, Edwards, Holly, Chu, Roland, Madlambayan, Gerard J, Taub, Jeffrey W, Wang, Zhihong, Wang, Yue, Li, Chunhuai, Lin, Hai, Ge, Yubin
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4847803/
https://ncbi.nlm.nih.gov/pubmed/26529495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1095406
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