CHK1 plays a critical role in the anti-leukemic activity of the wee1 inhibitor MK-1775 in acute myeloid leukemia cells

BACKGROUND: Acute myeloid leukemia (AML) remains a difficult disease to treat and requires new therapies to improve treatment outcome. Wee1 inhibitors have been used to prevent activation of the G2 cell cycle checkpoint, thus enhancing the antitumor activity of DNA damaging agents. In this study, we...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Hematol Oncol
मुख्य लेखकों: Qi, Wenxiu, Xie, Chengzhi, Li, Chunhuai, Caldwell, J Timothy, Edwards, Holly, Taub, Jeffrey W, Wang, Yue, Lin, Hai, Ge, Yubin
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: BioMed Central 2014
विषय:
Research
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237862/
https://ncbi.nlm.nih.gov/pubmed/25084614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-014-0053-9
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