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CHK1 plays a critical role in the anti-leukemic activity of the wee1 inhibitor MK-1775 in acute myeloid leukemia cells

BACKGROUND: Acute myeloid leukemia (AML) remains a difficult disease to treat and requires new therapies to improve treatment outcome. Wee1 inhibitors have been used to prevent activation of the G2 cell cycle checkpoint, thus enhancing the antitumor activity of DNA damaging agents. In this study, we...

詳細記述

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書誌詳細
出版年:J Hematol Oncol
主要な著者: Qi, Wenxiu, Xie, Chengzhi, Li, Chunhuai, Caldwell, J Timothy, Edwards, Holly, Taub, Jeffrey W, Wang, Yue, Lin, Hai, Ge, Yubin
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237862/
https://ncbi.nlm.nih.gov/pubmed/25084614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-014-0053-9
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