Mechanisms responsible for the synergistic antileukemic interactions between ATR inhibition and cytarabine in acute myeloid leukemia cells

Acute myeloid leukemia (AML) continues to be a challenging disease to treat, thus new treatment strategies are needed. In this study, we investigated the antileukemic effects of ATR inhibition alone or combined with cytarabine in AML cells. Treatment with the ATR-selective inhibitor AZ20 caused prol...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ma, Jun, Li, Xinyu, Su, Yongwei, Zhao, Jianyun, Luedtke, Daniel A., Epshteyn, Valeria, Edwards, Holly, Wang, Guan, Wang, Zhihong, Chu, Roland, Taub, Jeffrey W., Lin, Hai, Wang, Yue, Ge, Yubin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296912/
https://ncbi.nlm.nih.gov/pubmed/28176818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41950
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