Mechanisms responsible for the synergistic antileukemic interactions between ATR inhibition and cytarabine in acute myeloid leukemia cells

Acute myeloid leukemia (AML) continues to be a challenging disease to treat, thus new treatment strategies are needed. In this study, we investigated the antileukemic effects of ATR inhibition alone or combined with cytarabine in AML cells. Treatment with the ATR-selective inhibitor AZ20 caused prol...

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Foilsithe in:Sci Rep
Main Authors: Ma, Jun, Li, Xinyu, Su, Yongwei, Zhao, Jianyun, Luedtke, Daniel A., Epshteyn, Valeria, Edwards, Holly, Wang, Guan, Wang, Zhihong, Chu, Roland, Taub, Jeffrey W., Lin, Hai, Wang, Yue, Ge, Yubin
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2017
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296912/
https://ncbi.nlm.nih.gov/pubmed/28176818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41950
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