MECHANISMS OF SYNERGISTIC ANTILEUKEMIC INTERACTIONS BETWEEN VALPROIC ACID AND CYTARABINE IN PEDIATRIC ACUTE MYELOID LEUKEMIA

PURPOSE: To determine the possibility of synergistic anti-leukemic activity and the underlying molecular mechanisms associated with cytarabine combined with valproic acid (VPA) [a histone deacetylase inhibitor (HDACI) and an FDA-licensed drug for treating both children and adults with epilepsy] in p...

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Main Authors: Xie, Chengzhi, Edwards, Holly, Xu, Xuelian, Zhou, Hui, Buck, Steven A., Stout, Mark L., Yu, Qun, Rubnitz, Jeffrey E., Matherly, Larry H., Taub, Jeffrey W., Ge, Yubin
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018695/
https://ncbi.nlm.nih.gov/pubmed/20889917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-1707
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