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Valproic Acid Synergistically Enhances The Cytotoxicity of Clofarabine in Pediatric Acute Myeloid Leukemia Cells

BACKGROUND: Acute myeloid leukemia (AML) remains a major therapeutic challenge in pediatric oncology even with intensified cytarabine (ara-C)-based chemotherapy. Therefore, new therapies are urgently needed to improve treatment outcome of this deadly disease. In this study, we evaluated antileukemic...

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Detalhes bibliográficos
Main Authors: Xie, Chengzhi, Edwards, Holly, LoGrasso, Salvatore B., Buck, Steven A., Matherly, Larry H., Taub, Jeffrey W., Ge, Yubin
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396758/
https://ncbi.nlm.nih.gov/pubmed/22488775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.24152
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