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Enantioselective Dehydrogenative Heck Arylations of Trisubstituted Alkenes with Indoles to Construct Quaternary Stereocenters

An enantioselective, intermolecular dehydrogenative Heck arylation of trisubstituted alkenes to construct remote quaternary stereocenters has been developed. Using a new chiral pyridine oxazoline ligand, good to high enantioselectivity is achieved for various combinations of indole derivatives and t...

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Publicat a:J Am Chem Soc
Autors principals: Zhang, Chun, Santiago, Celine B., Crawford, Jennifer M., Sigman, Matthew S.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5039010/
https://ncbi.nlm.nih.gov/pubmed/26624236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b11335
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