The dynamics of genomic-length DNA molecules in 100-nm channels

We show that genomic-length DNA molecules imaged in nanochannels have an extension along the channel that scales linearly with the contour length of the polymer, in agreement with the scaling arguments developed by de Gennes for self-avoiding confined polymers. This fundamental relationship allows u...

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Bibliographic Details
Main Authors: Tegenfeldt, Jonas O., Prinz, Christelle, Cao, Han, Chou, Steven, Reisner, Walter W., Riehn, Robert, Wang, Yan Mei, Cox, Edward C., Sturm, James C., Silberzan, Pascal, Austin, Robert H.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC503729/
https://ncbi.nlm.nih.gov/pubmed/15252203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403849101
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