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Single-molecule denaturation mapping of DNA in nanofluidic channels

Here we explore the potential power of denaturation mapping as a single-molecule technique. By partially denaturing YOYO®-1-labeled DNA in nanofluidic channels with a combination of formamide and local heating, we obtain a sequence-dependent “barcode” corresponding to a series of local dips and peak...

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Autors principals: Reisner, Walter, Larsen, Niels B., Silahtaroglu, Asli, Kristensen, Anders, Tommerup, Niels, Tegenfeldt, Jonas O., Flyvbjerg, Henrik
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922186/
https://ncbi.nlm.nih.gov/pubmed/20616076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1007081107
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