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Integrated view of genome structure and sequence of a single DNA molecule in a nanofluidic device
We show how a bird’s-eye view of genomic structure can be obtained at ∼1-kb resolution from long (∼2 Mb) DNA molecules extracted from whole chromosomes in a nanofluidic laboratory-on-a-chip. We use an improved single-molecule denaturation mapping approach to detect repetitive elements and known as w...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3612670/ https://ncbi.nlm.nih.gov/pubmed/23479649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214570110 |
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