Integrated view of genome structure and sequence of a single DNA molecule in a nanofluidic device

We show how a bird’s-eye view of genomic structure can be obtained at ∼1-kb resolution from long (∼2 Mb) DNA molecules extracted from whole chromosomes in a nanofluidic laboratory-on-a-chip. We use an improved single-molecule denaturation mapping approach to detect repetitive elements and known as w...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Marie, Rodolphe, Pedersen, Jonas N., Bauer, David L. V., Rasmussen, Kristian H., Yusuf, Mohammed, Volpi, Emanuela, Flyvbjerg, Henrik, Kristensen, Anders, Mir, Kalim U.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Physical Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612670/
https://ncbi.nlm.nih.gov/pubmed/23479649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214570110
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi