Editor’s Highlight: Neonatal Activation of the Xenobiotic-Sensors PXR and CAR Results in Acute and Persistent Down-regulation of PPARα-Signaling in Mouse Liver

Safety concerns have emerged regarding the potential long-lasting effects due to developmental exposure to xenobiotics. The pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are critical xenobiotic-sensing nuclear receptors that are highly expressed in liver. The goal of this stud...

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Udgivet i:Toxicol Sci
Main Authors: Li, Cindy Yanfei, Cheng, Sunny Lihua, Bammler, Theo K., Cui, Julia Yue
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
PXR, CAR, and Downregulation of PPARa Signaling
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036618/
https://ncbi.nlm.nih.gov/pubmed/27413110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw127
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