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Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production
Immunomodulatory drugs (IMiDs) are a family of compounds derived from thalidomide. Binding of the IMiD molecule to the Lon protease Cereblon initiates the degradation of substrates via the ubiquitin proteasome pathway. Here, we show that Cereblon forms a complex with Rabex-5, a regulator of immune h...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5035883/ https://ncbi.nlm.nih.gov/pubmed/27601648 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611751113 |
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