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Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production
Immunomodulatory drugs (IMiDs) are a family of compounds derived from thalidomide. Binding of the IMiD molecule to the Lon protease Cereblon initiates the degradation of substrates via the ubiquitin proteasome pathway. Here, we show that Cereblon forms a complex with Rabex-5, a regulator of immune h...
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| Gepubliceerd in: | Proc Natl Acad Sci U S A |
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| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5035883/ https://ncbi.nlm.nih.gov/pubmed/27601648 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611751113 |
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