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Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production
Immunomodulatory drugs (IMiDs) are a family of compounds derived from thalidomide. Binding of the IMiD molecule to the Lon protease Cereblon initiates the degradation of substrates via the ubiquitin proteasome pathway. Here, we show that Cereblon forms a complex with Rabex-5, a regulator of immune h...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5035883/ https://ncbi.nlm.nih.gov/pubmed/27601648 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611751113 |
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