TLR4-induced IFN-γ production increases TLR2 sensitivity and drives Gram-negative sepsis in mice

Gram-negative bacterial infection is a major cause of sepsis and septic shock. An important inducer of inflammation underlying both syndromes is the cellular recognition of bacterial products through pattern recognition receptors (PRRs), including Toll-like receptors (TLRs). We identified a novel an...

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Detalhes bibliográficos
Main Authors: Spiller, Stephan, Elson, Greg, Ferstl, Ruth, Dreher, Stefan, Mueller, Thomas, Freudenberg, Marina, Daubeuf, Bruno, Wagner, Hermann, Kirschning, Carsten J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
Assuntos:
Brief Definitive Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525587/
https://ncbi.nlm.nih.gov/pubmed/18644971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20071990
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