Generation of anti-TLR2 intrabody mediating inhibition of macrophage surface TLR2 expression and TLR2-driven cell activation

BACKGROUND: Toll-like receptor (TLR) 2 is a component of the innate immune system and senses specific pathogen associated molecular patterns (PAMPs) of both microbial and viral origin. Cell activation via TLR2 and other pattern recognition receptors (PRRs) contributes to sepsis pathology and chronic...

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Main Authors: Kirschning, Carsten J, Dreher, Stefan, Maaß, Björn, Fichte, Sylvia, Schade, Jutta, Köster, Mario, Noack, Andreas, Lindenmaier, Werner, Wagner, Hermann, Böldicke, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873280/
https://ncbi.nlm.nih.gov/pubmed/20388199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-10-31
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