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Humanized cereblon mice revealed two distinct therapeutic pathways of immunomodulatory drugs
Immunomodulatory drugs (IMiDs), including thalidomide derivatives such as lenalidomide and pomalidomide, offer therapeutic benefit in several hematopoietic malignancies and autoimmune/inflammatory diseases. However, it is difficult to study the IMiD mechanism of action in murine disease models becau...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6243262/ https://ncbi.nlm.nih.gov/pubmed/30373817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814446115 |
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