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Humanized cereblon mice revealed two distinct therapeutic pathways of immunomodulatory drugs
Immunomodulatory drugs (IMiDs), including thalidomide derivatives such as lenalidomide and pomalidomide, offer therapeutic benefit in several hematopoietic malignancies and autoimmune/inflammatory diseases. However, it is difficult to study the IMiD mechanism of action in murine disease models becau...
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| Gepubliceerd in: | Proc Natl Acad Sci U S A |
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| Hoofdauteurs: | , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6243262/ https://ncbi.nlm.nih.gov/pubmed/30373817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814446115 |
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