CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and l-type Ca(2+) channels upstream of p38 MAPK

BACKGROUND: The chemokine receptor CXCR4 (CD184) and its natural ligand CXCL12 contribute to many physiological processes, including decisions about cell death and survival in the central nervous system. In addition, CXCR4 is a co-receptor for human immunodeficiency virus (HIV)-1 and mediates the ne...

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Vydáno v:J Neuroinflammation
Hlavní autoři: Sanchez, Ana B., Medders, Kathryn E., Maung, Ricky, Sánchez-Pavón, Paloma, Ojeda-Juárez, Daniel, Kaul, Marcus
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035480/
https://ncbi.nlm.nih.gov/pubmed/27664068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0724-2
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