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NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation
The altered function and/or structure of tau protein is postulated to cause cell death in tauopathies and Alzheimer’s disease. However, the mechanisms by which tau induces neuronal death remain unclear. Here we show that overexpression of human tau and of some of its N-terminal fragments in primary...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1413822/ https://ncbi.nlm.nih.gov/pubmed/16477009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0511065103 |
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