NGF-Dependent Changes in Ubiquitin Homeostasis Trigger Early Cholinergic Degeneration in Cellular and Animal AD-Model

Basal forebrain cholinergic neurons (BFCNs) depend on nerve growth factor (NGF) for their survival/differentiation and innervate cortical and hippocampal regions involved in memory/learning processes. Cholinergic hypofunction and/or degeneration early occurs at prodromal stages of Alzheimer’s diseas...

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Publicado en:Front Cell Neurosci
Autores principales: Latina, Valentina, Caioli, Silvia, Zona, Cristina, Ciotti, Maria Teresa, Borreca, Antonella, Calissano, Pietro, Amadoro, Giuseppina
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6300588/
https://ncbi.nlm.nih.gov/pubmed/30618634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2018.00487
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