CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and l-type Ca(2+) channels upstream of p38 MAPK

BACKGROUND: The chemokine receptor CXCR4 (CD184) and its natural ligand CXCL12 contribute to many physiological processes, including decisions about cell death and survival in the central nervous system. In addition, CXCR4 is a co-receptor for human immunodeficiency virus (HIV)-1 and mediates the ne...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neuroinflammation
Prif Awduron: Sanchez, Ana B., Medders, Kathryn E., Maung, Ricky, Sánchez-Pavón, Paloma, Ojeda-Juárez, Daniel, Kaul, Marcus
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2016
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035480/
https://ncbi.nlm.nih.gov/pubmed/27664068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0724-2
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