CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and l-type Ca(2+) channels upstream of p38 MAPK

BACKGROUND: The chemokine receptor CXCR4 (CD184) and its natural ligand CXCL12 contribute to many physiological processes, including decisions about cell death and survival in the central nervous system. In addition, CXCR4 is a co-receptor for human immunodeficiency virus (HIV)-1 and mediates the ne...

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Detalles Bibliográficos
Publicado en:J Neuroinflammation
Main Authors: Sanchez, Ana B., Medders, Kathryn E., Maung, Ricky, Sánchez-Pavón, Paloma, Ojeda-Juárez, Daniel, Kaul, Marcus
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2016
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035480/
https://ncbi.nlm.nih.gov/pubmed/27664068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0724-2
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