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Bioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes
The formation of drug-protein adducts via metabolic activation and covalent binding may stimulate an immune response or may result in direct cell toxicity. Protein covalent binding is a potentially pivotal step in the development of idiosyncratic adverse drug reactions (IADRs). Trimethoprim (TMP)-su...
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| Publicado en: | Drug Metab Dispos |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The American Society for Pharmacology and Experimental Therapeutics
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5034695/ https://ncbi.nlm.nih.gov/pubmed/27457783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.072041 |
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