Chargement en cours...
Bioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes
The formation of drug-protein adducts via metabolic activation and covalent binding may stimulate an immune response or may result in direct cell toxicity. Protein covalent binding is a potentially pivotal step in the development of idiosyncratic adverse drug reactions (IADRs). Trimethoprim (TMP)-su...
Enregistré dans:
| Publié dans: | Drug Metab Dispos |
|---|---|
| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The American Society for Pharmacology and Experimental Therapeutics
2016
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5034695/ https://ncbi.nlm.nih.gov/pubmed/27457783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.072041 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|