Goat K(222)-PrP(C) polymorphic variant does not provide resistance to atypical scrapie in transgenic mice

Host prion (PrP(C)) genotype is a major determinant for the susceptibility to prion diseases. The Q/K(222)-PrP(C) polymorphic variant provides goats and mice with high resistance against classical scrapie and bovine spongiform encephalopathy (BSE); yet its effect against atypical scrapie is unknown....

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Dettagli Bibliografici
Pubblicato in:Vet Res
Autori principali: Aguilar-Calvo, Patricia, Espinosa, Juan-Carlos, Andréoletti, Olivier, González, Lorenzo, Orge, Leonor, Juste, Ramón, Torres, Juan-María
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034450/
https://ncbi.nlm.nih.gov/pubmed/27659200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13567-016-0380-7
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