Effects of sphingosine-1-phosphate receptor 1 phosphorylation in response to FTY720 during neuroinflammation

Fingolimod (FTY720, Gilenya), a sphingosine-1-phosphate receptor (S1PR) modulator, is one of the first-line immunomodulatory therapies for treatment of relapsing-remitting multiple sclerosis (MS). Human S1PR1 variants have been reported to have functional heterogeneity in vitro, suggesting that S1PR...

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Udgivet i:JCI Insight
Main Authors: Tsai, Hsing-Chuan, Huang, Yingxiang, Garris, Christopher S., Moreno, Monica A., Griffin, Christina W., Han, May H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033897/
https://ncbi.nlm.nih.gov/pubmed/27699272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86462
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