Defective sphingosine-1-phosphate receptor 1 (S1P(1)) phosphorylation exacerbates T(H)17-mediated autoimmune neuroinflammation

Sphingosine-1-phosphate (S1P) signaling regulates lymphocyte egress from lymphoid organs into systemic circulation. Sphingosine phosphate receptor 1 (S1P(1)) agonist, FTY-720 (Gilenya™) arrests immune trafficking and prevents multiple sclerosis (MS) relapses. However, alternative mechanisms of S1P-S...

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Hlavní autoři: Garris, Christopher S., Wu, Linfeng, Acharya, Swati, Arac, Ahmet, Blaho, Victoria A., Huang, Yingxiang, Moon, Byoung San, Axtell, Robert C., Ho, Peggy P., Steinberg, Gary K., Lewis, David B., Sobel, Raymond A., Han, David K., Steinman, Lawrence, Snyder, Michael P., Hla, Timothy, Han, May H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014310/
https://ncbi.nlm.nih.gov/pubmed/24076635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2730
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