Defective sphingosine-1-phosphate receptor 1 (S1P(1)) phosphorylation exacerbates T(H)17-mediated autoimmune neuroinflammation

Sphingosine-1-phosphate (S1P) signaling regulates lymphocyte egress from lymphoid organs into systemic circulation. Sphingosine phosphate receptor 1 (S1P(1)) agonist, FTY-720 (Gilenya™) arrests immune trafficking and prevents multiple sclerosis (MS) relapses. However, alternative mechanisms of S1P-S...

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Autors principals: Garris, Christopher S., Wu, Linfeng, Acharya, Swati, Arac, Ahmet, Blaho, Victoria A., Huang, Yingxiang, Moon, Byoung San, Axtell, Robert C., Ho, Peggy P., Steinberg, Gary K., Lewis, David B., Sobel, Raymond A., Han, David K., Steinman, Lawrence, Snyder, Michael P., Hla, Timothy, Han, May H.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014310/
https://ncbi.nlm.nih.gov/pubmed/24076635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2730
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