HDL-bound sphingosine 1-phosphate restrains lymphopoiesis and neuroinflammation

Lipid mediators influence immunity in myriad ways. For example, circulating sphingosine 1-phosphate (S1P) is a key regulator of lymphocyte egress(1,2). Although the majority of plasma S1P is bound to apolipoprotein M (ApoM) in the high-density lipoprotein (HDL) particle(3), immunological functions o...

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Publicado en:Nature
Main Authors: Blaho, Victoria A., Galvani, Sylvain, Engelbrecht, Eric, Liu, Catherine, Swendeman, Steven L., Kono, Mari, Proia, Richard L., Steinman, Lawrence, Han, May H., Hla, Timothy
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506268/
https://ncbi.nlm.nih.gov/pubmed/26053123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14462
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