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HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P(1) to limit vascular inflammation

The sphingosine 1-phosphate receptor 1 (S1P(1)) is abundant in endothelial cells, where it regulates vascular development and microvascular barrier function. In investigating the role of endothelial cell S1P(1) in adult mice, we found that the endothelial S1P(1) signal was enhanced in regions of the...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Galvani, Sylvain, Sanson, Marie, Blaho, Victoria A., Swendeman, Steven L., Obinata, Hideru, Conger, Heather, Dahlbäck, Björn, Kono, Mari, Proia, Richard L., Smith, Jonathan D., Hla, Timothy
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4768813/
https://ncbi.nlm.nih.gov/pubmed/26268607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaa2581
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