Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs

Excitatory neurotransmission plays a key role in epileptogenesis. Correspondingly, AMPA-subtype ionotropic glutamate receptors, which mediate the majority of excitatory neurotransmission and contribute to seizure generation and spread, have emerged as promising targets for epilepsy therapy. The most...

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Bibliographic Details
Published in:Neuron
Main Authors: Yelshanskaya, Maria V., Singh, Appu K., Sampson, Jared M., Narangoda, Chamali, Kurnikova, Maria, Sobolevsky, Alexander I.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033713/
https://ncbi.nlm.nih.gov/pubmed/27618672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.08.012
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