Inhibition of mast cell-secreted histamine decreases biliary proliferation and fibrosis in primary sclerosing cholangitis Mdr2(−/−) mice

BACKGROUND AND AIM: Hepatic fibrosis is marked by activation of hepatic stellate cells (HSCs). Cholestatic injury precedes liver fibrosis and cholangiocytes interact with HSCs promoting fibrosis. Mast cells (MCs) infiltrate following liver injury and release histamine increasing biliary proliferatio...

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Veröffentlicht in:Hepatology
Hauptverfasser: Jones, Hannah, Hargrove, Laura, Kennedy, Lindsey, Meng, Fanyin, Graf-Eaton, Allyson, Owens, Jennifer, Alpini, Gianfranco, Johnson, Christopher, Bernuzzi, Francesca, Demieville, Jennifer, DeMorrow, Sharon, Invernizzi, Pietro, Francis, Heather
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033697/
https://ncbi.nlm.nih.gov/pubmed/27351144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28704
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