Inhibition of Mast Cell-Derived Histamine Decreases Human Cholangiocarcinoma Growth and Differentiation via c-Kit/Stem Cell Factor–Dependent Signaling

The tumor microenvironment of cholangiocarcinoma (CCA) is composed of numerous cells, including mast cells (MCs). MCs release histamine, which increases CCA progression and angiogenesis. Cholangiocytes secrete stem cell factor, which functions via the MC growth factor receptor c-Kit. Here, we show t...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Pathol
Prif Awduron: Johnson, Christopher, Huynh, Victoria, Hargrove, Laura, Kennedy, Lindsey, Graf-Eaton, Allyson, Owens, Jennifer, Trzeciakowski, Jerome P., Hodges, Kyle, DeMorrow, Sharon, Han, Yuyan, Wong, Lucas, Alpini, Gianfranco, Francis, Heather
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Investigative Pathology 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707204/
https://ncbi.nlm.nih.gov/pubmed/26597881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.09.016
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