Inhibition of Mast Cell-Derived Histamine Decreases Human Cholangiocarcinoma Growth and Differentiation via c-Kit/Stem Cell Factor–Dependent Signaling

The tumor microenvironment of cholangiocarcinoma (CCA) is composed of numerous cells, including mast cells (MCs). MCs release histamine, which increases CCA progression and angiogenesis. Cholangiocytes secrete stem cell factor, which functions via the MC growth factor receptor c-Kit. Here, we show t...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Johnson, Christopher, Huynh, Victoria, Hargrove, Laura, Kennedy, Lindsey, Graf-Eaton, Allyson, Owens, Jennifer, Trzeciakowski, Jerome P., Hodges, Kyle, DeMorrow, Sharon, Han, Yuyan, Wong, Lucas, Alpini, Gianfranco, Francis, Heather
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707204/
https://ncbi.nlm.nih.gov/pubmed/26597881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.09.016
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