The Transcriptional Repressive Activity of KRAB Zinc Finger Proteins Does Not Correlate with Their Ability to Recruit TRIM28

KRAB domain Zinc finger proteins are one of the most abundant families of transcriptional regulators in higher vertebrates. The prevailing view is that KRAB domain proteins function as potent transcriptional repressors by recruiting TRIM28 and promoting heterochromatin spreading. However, the extent...

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Udgivet i:PLoS One
Main Authors: Murphy, Kristin E., Shylo, Natalia A., Alexander, Katherine A., Churchill, Angela J., Copperman, Cecilia, García-García, María J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033580/
https://ncbi.nlm.nih.gov/pubmed/27658112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163555
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