Recombinant Atrial Natriuretic Peptide Prevents Aberrant Ca(2+) Leakage through the Ryanodine Receptor by Suppressing Mitochondrial Reactive Oxygen Species Production Induced by Isoproterenol in Failing Cardiomyocytes

Catecholamines induce intracellular reactive oxygen species (ROS), thus enhancing diastolic Ca(2+) leakage through the ryanodine receptor during heart failure (HF). However, little is known regarding the effect of atrial natriuretic peptide (ANP) on ROS generation and Ca(2+) handling in failing card...

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Veröffentlicht in:PLoS One
Hauptverfasser: Murakami, Wakako, Kobayashi, Shigeki, Susa, Takehisa, Nanno, Takuma, Ishiguchi, Hironori, Myoren, Takeki, Nishimura, Shigehiko, Kato, Takayoshi, Hino, Akihiro, Oda, Tetsuro, Okuda, Shinichi, Yamamoto, Takeshi, Yano, Masafumi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033569/
https://ncbi.nlm.nih.gov/pubmed/27657534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163250
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