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In vitro cytotoxicity and in vivo efficacy, pharmacokinetics and metabolism of pyrazole-based small-molecule inhibitors of Mdm2/4-p53 interaction
PURPOSE: The interaction of p53, with its negative regulators Mdm2/4 has been widely studied [1]. In p53(+/+) cells, expression of Mdm2/4 leads to p53 turnover, inhibition of downstream transcription, decreasing cell cycle arrest or apoptosis. We report in vitro cytotoxicity and in vivo efficacy, ph...
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| Publicado no: | Cancer Chemother Pharmacol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5033042/ https://ncbi.nlm.nih.gov/pubmed/26050209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-015-2791-y |
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