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Treatment of spontaneous EAE by laquinimod reduces Tfh, B cell aggregates, and disease progression

OBJECTIVE: To evaluate the influence of oral laquinimod, a candidate multiple sclerosis (MS) treatment, on induction of T follicular helper cells, development of meningeal B cell aggregates, and clinical disease in a spontaneous B cell–dependent MS model. METHODS: Experimental autoimmune encephalomy...

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Detalhes bibliográficos
Publicado no:Neurol Neuroimmunol Neuroinflamm
Main Authors: Varrin-Doyer, Michel, Pekarek, Kara L., Spencer, Collin M., Bernard, Claude C.A., Sobel, Raymond A., Cree, Bruce A.C., Schulze-Topphoff, Ulf, Zamvil, Scott S.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5032667/
https://ncbi.nlm.nih.gov/pubmed/27704036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/NXI.0000000000000272
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