Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2

Dimethyl fumarate (DMF) (BG-12, Tecfidera) is a fumaric acid ester (FAE) that was advanced as a multiple sclerosis (MS) therapy largely for potential neuroprotection as it was recognized that FAEs are capable of activating the antioxidative transcription factor nuclear factor (erythroid-derived 2)-l...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Schulze-Topphoff, Ulf, Varrin-Doyer, Michel, Pekarek, Kara, Spencer, Collin M., Shetty, Aparna, Sagan, Sharon A., Cree, Bruce A. C., Sobel, Raymond A., Wipke, Brian T., Steinman, Lawrence, Scannevin, Robert H., Zamvil, Scott S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855599/
https://ncbi.nlm.nih.gov/pubmed/27078105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603907113
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