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Follicular helper T cells progressively differentiate to regulate the germinal center response
Germinal center (GC) B cells undergo affinity selection, dependent upon interactions with CD4(+) follicular helper T (T(FH)) cells. We demonstrate that T(FH) cells progressed through transcriptionally and functionally distinct stages, providing differential signals for GC regulation. They initially...
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| Pubblicato in: | Nat Immunol |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5030190/ https://ncbi.nlm.nih.gov/pubmed/27573866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3554 |
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