Dynamic signaling by T follicular helper cells during germinal center B cell selection

T follicular helper (T(FH)) cells select high-affinity, antibody-producing B cells for clonal expansion in germinal centers (GCs), but the nature of their interaction is not well defined. Using intravital imaging, we found that selection is mediated by large but transient contacts between T(FH) and...

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Udgivet i:Science
Main Authors: Shulman, Ziv, Gitlin, Alexander D., Weinstein, Jason S., Lainez, Begoña, Esplugues, Enric, Flavell, Richard A., Craft, Joseph E., Nussenzweig, Michel C.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4519234/
https://ncbi.nlm.nih.gov/pubmed/25170154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1257861
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