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Clonal selection in the germinal center by regulated proliferation and hypermutation
During immune responses, B lymphocytes clonally expand and undergo secondary diversification of their immunoglobulin (Ig) genes in germinal centers (GCs)(1–4). High affinity B cells are expanded through iterative interzonal cycles of division and hypermutation in the GC dark zone (DZ) followed by mi...
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| Publicado en: | Nature |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4271732/ https://ncbi.nlm.nih.gov/pubmed/24805232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13300 |
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